In multiple myeloma (MM), interaction with bone marrow stromal cells (BMSCs) via CD40CD40 ligand (CD40LG) signaling increases iron accumulation and activates the steroid biosynthesis pathway in MM cells, leading to enhanced lanosterol production
This peptide was first isolated and identified in the 1990s by Croatian researchers, who observed its remarkable protective properties on gastrointestinal tract tissues
This mechanism represents a control of the influx of fatty acyl units into mitochondria in response to the intra-mitochondrial acetyl-CoA level, in addition to the finely regulated mechanism of CPT1 by malonyl-CoA
Ethics statement The animal study was reviewed and approved by the Laboratory Animal Welfare and Ethics Committee of Fourth Military Medical University
Blood does not usually mix with the stool, but instead coats the outer surface or is visible on toilet paper
doi: 10.1016/j.cgh.2019.07.045 3 Van CutsemESagaertXTopalBHaustermansKPrenenH