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Marashly, [email protected] Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Inserting the needle smoothly at the appropriate angle (90 degrees for IM, 45-90 degrees for SC depending on subcutaneous tissue thickness)

Subcutaneous fat surrounding the knee provides adequate proximity for peptide diffusion to deeper structures