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Currently in Phase III trials, Fosmanogepix has demonstrated efficacy in early studies for invasive candidiasis and is considered a promising candidate for drug-resistant or difficult-to-treat infections

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R Histamine intolerance and mast cell activation: HNMT is the primary intracellular histamine degradation enzyme, and it depends entirely on SAM-e for its methyl donor

The monitoring frequency is adjusted according to the grade of dysplasia, with ACG guidelines indicating that BE patients without dysplasia may be monitored every 35 years, whereas patients with LGIN require more frequent monitoring (initially every 612 months, then annually)