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Signs your medication may not be working If you have been on tirzepatide for four or more weeks with absolutely no appetite reduction, no weight change, and no GI effects, something may be wrong

Both of these forms are composed of similar active pharmaceutical ingredients

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These day to day differences show up in how quickly hunger returns, how big meals feel, and how much water and fiber are needed, so tracking a simple symptom diary for a month or two can reveal patterns and help a clinician decide whether to adjust the dose or switch therapies