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By the studys end, liraglutide had elevated testosterone and SHBG to higher levels than achieved in the other groups and led to higher sperm counts and motility, earning the authors conclusion that liraglutide is a useful drug for the treatment of obese males with metabolic hypogonadism, outperforming traditional hormonal approaches This pioneering trial suggests that tackling the root cause (obesity/insulin resistance) with a GLP-1 RA can reverse obesity-related hypogonadism and improve fertility potential in men

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Early GLP-1 therapy is gaining attention as clinicians rethink traditional treatment timelines

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Gumen AV, Kozinets IA, Shanin SN, Malinin VV, Rybakina EG