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Post-treatment, the cells were washed with 1X phosphate-buffered saline and stained with 15 M DCFDA-H2 or 5 M MitoSOX for 15 min at 37 C
Banci) 3751 (2001)
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Weight reduction: In the phase 2 trial, cagrilintide 4.5 mg weekly produced approximately 10.8% body weight loss over 26 weeks versus 3.0% with placebo [4]
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It also mitigates mitochondrial oxidative stress in microglia exposed to glutamate and reduces excitotoxicity-induced neuronal apoptosis via activation of the Nrf-2/HO-1 pathway [127]
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