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Once reconstituted, the peptide bonds become vulnerable again to aqueous hydrolysis, and oxidation of susceptible residues (tryptophan and methionine analogs in the sequence) begins
Clinical monitoring and patient safety advice includes: Gastrointestinal symptoms : Patients should report severe or persistent nausea, vomiting, or abdominal pain, which may indicate pancreatitis (a warning in tirzepatide labeling) or require dose adjustment
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Water is ideal, but oral rehydration solutions (available from pharmacies) can help replace lost electrolytes
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Participants receiving semaglutide 2.4 mg weekly lost an average of 22 percent of their starting body weight compared to 2 percent in the placebo group
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