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Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)
El promedio de la prdida de peso, en 6 meses de tratamiento con 3 cpsula diarias, puede variar entre 9 y 13.5 kilogramos, mientras que la circunferencia de cintura puede reducirse 12.8 cm en promedio
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