BMI is a crude measure of adiposity that does not assess body composition or quantity of visceral fat, which has more deleterious effects in HFpEF 6,16 , limiting insight on the effect of semaglutide on visceral fat loss and its association with improvements in KCCQ-CSS and 6MWD outcomes
Additional benefits of semaglutide include reductions in body weight, systolic blood pressure, and inflammatory markers, all of which contributed to improved cardiovascular outcomes
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GLP-1 medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
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