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Agonism of GPR119 in both healthy or diabetic and obese mice, is known to improve glucose tolerance (90), or even prevent atherosclerosis in mice (332), while at the same time inducing the secretion of glucagon under low glucose levels avoiding hypoglycaemia (91)
Hernandez AF, Green JB, Janmohamed S, D'Agostino RB Sr, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC
Adems se ha asociado aparicin de colestasis a la administracin de lpidos por encima de 1 g/kg/da (pacientes adultos)
Additionally, another major member of incretins, GIP, and its analogs have also demonstrated neuroprotective effects in disease animal models and can enhance the effects of GLP-1
Furthermore, semaglutide prevents MASLD/MASH-driven HCC progression in metabolic preclinical models, partly by correcting adipokine imbalances (low adiponectin, high leptin) associated with insulin resistance, which removes a key chronic inflammatory and pro-oncogenic signal linked to the disease (Kojima et al., 2020)
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