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When intrinsic renal cells become activated, they secrete cytokines like TGF- and CTGF that facilitate the formation of myofibroblasts which contribute to fibrosis by producing collagen I, collagen III, collagen IV, fibronectin, and laminin

[12] Contemporary reporting described the death as a myocardial infarction occurring in a participant who had received the eleventh weekly dose, and the trials attending physician considered the most likely explanation to be pre-existing asymptomatic coronary artery disease rather than the study drug

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The dose-response curve explained At the 1mg level, participants lost 8.7% of body weight over 48 weeks

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