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When regulators accept biomarkers closely tied to aging biology as endpoints for clinical trials, they are creating new regulatory on-ramps for therapies that preserve function and extend healthy lifespaneven without explicit approval for "aging." For drug developers, validated surrogate endpoints like BMD can mean smaller and shorter pivotal trials to test those targets clinically
Plateaus, discontinuation, and what happens next Weight-loss plateaus pauses in your weight loss are common during GLP-1 treatment
Ozempic (subcutaneous semaglutide) is approved for reducing major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, as well as reducing the risk of sustained kidney function decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease
Thats when clinical experience stops being anecdotal
The following is not intended as medical advice
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