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Strategies to enhance the tolerability of GLP-1-based therapy might include identification of agents that stimulate release of endogenous GLP-1 from intestinal L-cells, potentially accompanied by fewer adverse effects

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Reformulate when possible

Tshala and Boivin and individuals recruited for the 2021 validation sibling cohort were also familiar and participants in long-term studies conducted in Kahemba by Drs

Higher doses, while more effective for weight loss, may increase the risk of exacerbating reflux symptoms, whereas lower doses may have a lesser impact

CrossRef GOLM1 and bile acid synthesis: Correspondence to editorial on GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Jing Lin, Jin-Hong Chen Clinical and Molecular Hepatology .2025