In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)
It supports fat metabolism, but exercise increases energy demand and enhances fat utilisation
This creates accountability
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How to Prevent Melasma from Coming Back Melasma thrives on consistency in the wrong direction, so flipping that script with structured maintenance keeps patches from returning
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