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Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

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While on the medication, semaglutide helps regulate appetite by mimicking the natural hormone GLP-1

Common issues include nausea and diarrhea, but complications can also extend to conditions such as gastroesophageal reflux disease, gastroparesis (paralysis of the stomach), and colonic inflammation

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Once-weekly semaglutide is a novel long-acting GLP-1RA