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DMT1, a member of solute carrier family 11 member 2 (SLC11A2), plays a role in iron transport, and its expression would be increased if exposed to high-iron environment
However, an increase in the urine protein-to-creatinine ratio was observed in the placebo group compared to the 1 mg/kg fresolimumab group, and a non-significant but greater decline in the estimated glomerular filtration rate (eGFR) was seen in the placebo group compared with both fresolimumab-treated groups [83]
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of these, 84 had paired samples available for epigenetic analysis
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