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(37) reported that the mRNA expression of IL-1 in cultured bovine alveolar macrophages reached its maximum at 1 to 2 h following incubation with LPS from Pasteurella haemolytica and was not detectable 24 h after stimulation, indicating a downregulation of this cytokine
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The researchers identified all individuals aged 60 years or older who initiated one or more of the three drug classes, for a total sample comprising more than 430,000 patients
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