glp-1 agonists and sglt2 inhibitors combination receptor agonists: a sound A retrospective analysis of combination

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[48-51] In parallel with achieving the A1c goal, it is also recommended that GLP-1RA or SGLT2i be included for patients with T2D with or at high risk of ASCVD to reduce cardiorenal risk, irrespective of A1c

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380 Firstly, the expression of GLP-1R is enhanced in the inflamed muscle fibers under pathological conditions, revealing the critical role of GLP-1R in regulating the muscles response to inflammation

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Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]