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We identified downregulation of mitochondrial programs in multiple non-proximal tubular cell populations compared with their counterparts in healthy kidneys
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Notably, identical lactate concentrations exert diametrically contrasting effects on ferroptosis susceptibility in malignant lung cancer cells compared with their normal epithelial counterparts, highlighting fundamental differences in lactate metabolism between these cellular contexts (82,99)
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J Clin Investig 126(3):837853 Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S (2010) Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice
When the CREBH protein is proteolyzed the N-terminal fragment is released and migrates to the nucleus where it functions as a transcription factor
