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Hormonal shifts may play a part for women, too

Body weight and composition may theoretically influence drug distribution, as semaglutide binds extensively to albumin and distributes into tissues

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A good example of this is growth hormone secretagogues peptides that facilitate growth hormone secretion whose capacity to promote physical growth can trigger the growth and spread of tumors.18 For that reason, peptides such as sermorelin, tesamorelin, and CJC-1295 are contraindicated for people with active cancer, as well as those with a personal or familial history of cancer

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Body fat acts as insulation, helping maintain warmth