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Psychiatry 27 (1), 118
have recently shown in a mouse model of 22q11.2DS that mitochondria were damaged in cortical layer 2/3 [359]
These findings comprehensively address the in vivo stability, retention, and drug release properties of the G/D-CuP hydrogel, supporting its potential for therapeutic applications
FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
(2020, April 24)
The healthy mice are given an oral administration of LA at 50mg/kg (LA-50) or 100mg/kg (LA-100)
