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ALC is naturally synthesized in our bodies on an ongoing basis, and crosses the blood/brain barrier, therefore potentially affecting brain hormones, chemistry, or brain function

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One addresses the hormonal changes that occur during menopause

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Split dosing becomes valuable when single dosing produces inconsistent results, when doses above 400mcg are needed, or when evening administration fits better into lifestyle patterns

Importantly, these differences were not large enough to change the half-life or overall clearance timeline of about five to seven weeks