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Additional risk factors include: Previous significant weight fluctuations or yo-yo dieting Genetic factors affecting skin quality and collagen production Smoking history, which impairs skin elasticity Inadequate protein intake during weight loss, leading to muscle loss Insufficient resistance exercise to maintain muscle mass Dehydration or poor nutritional status Patients with multiple risk factors should discuss realistic expectations with their GP or diabetes specialist nurse before commencing semaglutide therapy

Gastroenterol Res Pract (2014) 2014:803185

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