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The increased risk of DKA in the SGLT2i group, and the associated hospitalisation, was not great enough to offset the increased rate of hospitalisation of any cause in the GLP-1 RA group
These effects typically resolve within days
A beneficial aspect of this combination is that dihydropyridine calcium channel blockers may help counteract the mild increase in heart rate occasionally observed with GLP-1 receptor agonists like Mounjaro
While the study cannot prove GLP-1 drugs caused low testosterone levels to normalize, it does show a direct correlation, Portillo Canales noted
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