potential side effects of semaglutide long term for weight loss Two-year in adults with overweight or obesity: the STEP 5 trial Ozempic Injection For Medical Weight – What are the therapeutic effects

Springer Nature

It is currently completing Phase 3 TRIUMPH trials and is available for research use in lyophilized (freeze-dried powder) form for the latest on [when retatrutide will be FDA approved](/guides/retatrutide-fda-approval-2026-timeline-status), see our regulatory timeline tracker

Both medications have side effects, and these can impact a persons overall health and well-being

A healthcare provider will determine eligibility based on your health

Semaglutide, the active ingredient in Ozempic, is also found in other weight loss treatments like Wegovy, which is specifically approved for weight loss

Its also important to note that individual responses to medications vary, and metformin or GLP-1s may not be right for everyone