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Treatment for HACE involves immediate descent and medical care immediately

Allergic reactions: Signs may include swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, severe rash or itching, dizziness, or a rapid heartbeat

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Body weight was also reduced with oral semaglutide versus placebo in healthy subjects

In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)