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People often call it the "bodyguard peptide" because its healing effects are remarkable
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Higher doses or more frequent treatments typically lead to higher costs
Furthermore, microinjections of leptin in rodents, into the ventromedial hypothalamus (VMH) 21 and the arcuate nucleus (ARC) 22 can decrease food intake massively, suggesting that leptins actions are mediated mainly by the hypothalamus
All mice were from a C57BL/6 background and were group-housed and maintained in individual ventilated cages with standard bedding and enrichment in a temperature- and humidity-controlled room on a 12-h light:dark cycle (lights on 7:00) with AL access to food (standard diet, Scientific Animal Food Engineering, or 45% HFD) and water unless otherwise stated
