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This warning is based on findings in rodent studies where these drugs caused thyroid C-cell tumors (medullary thyroid carcinoma) at clinically relevant exposures

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doi: 10.1038/ni.3800 115 DiefenbachAJensenERJamiesonAMRauletDH

Johns Wort and PPR, for example, induce CYP3A4 and P-gp, increasing the clearance of oral contraceptives, antivirals, and immunosuppressants (84)