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In Laymans terms

Vitamin B12 shots may not be suitable for people with a history of: sensitivity to vitamin B12 Lebers disease, which affects the optic nerve kidney problems hypokalemia, or low potassium levels deficiencies in other nutrients, particularly folic acid and iron Vitamin B12 injections provide the individual with a synthetic version of vitamin B12

while there is no evidence of harm at that level, caution is advised

In C57BL/6 mice, the absence of either protein leads to deficient type I IFN production and early mortality (98)

Minimize room temperature exposure

If you take more than what is required, you may experience intense and severe side-effects