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These agents modulate neurotransmission, reduce neuroinflammation and oxidative stress, enhance mitochondrial and neurotrophic function, and improve insulin sensitivity and hypothalamic-pituitary-adrenal (HPA) axis regulation

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GLP-1 fatigue is a well-documented side effect that tends to worsen during periods of dosing instability

These minor reactions are typical, but its important to recognize when something more serious might be happening

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Its role appears modulatory rather than suppressive, supporting coordinated neural and endocrine timing rather than inducing forced sleep states