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7 In line with the overall theme of patient-centered care, the ADAs recommendations for intensification beyond metformin monotherapy include careful consideration of patient- and drug-related factors when determining the best regimen for a given patient

Metformin increases the body's own production of GLP-1, potentially mimicking some of the effects of GLP-1 receptor agonists

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The neurological phenotype has been primarily attributed to impaired global seryl-tRNA charging in neurons

The ROMK protein is a member of the inwardly rectifying K + channel proteins that are also designated K ir with ROMK being K ir 1.1 (three isoforms of ROMK result from alternative splicing: K ir 1.1a, K ir 1.1b, and K ir 1.1c)

Conclusion/interpretation: We found evidence for adverse offspring effects of GLP-1 agonists and SGLT2 inhibitors also in human studies