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Collectively, the preclinical literature demonstrates that GLP-1RAs attenuate phasic dopamine responses and diminish the reinforcing properties of addictive substances

71.2 lbs on average) Retatrutide 9mg: 26.4% body weight reduction Tirzepatide/Zepbound (Phase 3 comparison, not head-to-head): ~20.9% Semaglutide/Wegovy (Phase 3 comparison, not head-to-head): ~14.9% Placebo: ~2.1% Note: These figures come from separate Phase 3 trials and are not direct head-to-head comparisons

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Furthermore, choline converts to betaine, which serves as a methyl donor and helps convert homocysteine back to methionine (1)

Pfizer Provides Update on GLP-1-RA clinical development program for adults with obesity and type 2 diabetes mellitus | Pfizer

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