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Furthermore, as this model does not require additional water supply, transitioning from a liquid diet to solid food with water may affect the mices physiological state

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1-3 Breast cancer therapies such as chemotherapy and endocrine therapy may contribute to weight gain, worsen metabolic dysfunction, and be less effective in patients with obesity

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For most licensed weight loss medicines, menstrual changes are not a direct pharmacological effect of the drug itself, but rather a secondary consequence of significant or rapid weight loss and the associated changes in energy availability and body composition