glp-1 news november 3 2025 Pipeline Update: August - Prime Therapeutics GLP-1 Trends

While GLP-1 receptor expression is absent in hepatocytes, GLP-1 receptor agonism exerts profound hepatic benefits through multiple indirect mechanisms

Seth P, Wu X, Huang W, Leibach FH, Ganapathy V: Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function

This breakthrough offers new hope for millions of patients struggling with diabetes-related kidney complications, providing a more effective treatment option to improve long-term health outcomes

The same study found that diets high in olive oil lower glucose levels after eating and when fasting

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However low, a certain degree of excretion in human milk is expected as animal data is a reliable predictor of the presence of a drug and/or its active metabolite(s) in human milk (52)