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Norhammar AM, Rydn L, Malmberg K: Admission plasma glucose
Inagaki N & Yamane S
Some patients experience therapeutic benefits without significant gastrointestinal symptoms, particularly when dose escalation follows the recommended gradual schedule
For individuals enrolled in clinical trials of retatrutide, trial protocols typically require full disclosure of all concurrent supplement use, and some protocols may restrict or prohibit certain supplements during the trial period
GLP-1 agonists (semaglutide, tirzepatide) modulate insulin and glucagon secretion
Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients
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