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Furthermore, long-standing type 2 diabetes can reduce beta-cell responsiveness, making GLP-1 therapies less effective
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A complete PA submission typically includes: Patient demographics, current BMI with date of measurement, weight history showing chronicity, qualifying comorbidities with ICD-10 codes, documented prior weight-loss attempts and outcomes, prior pharmacotherapy trials and reasons for failure or intolerance, the prescriber's clinical rationale for the requested medication, and contraindications to alternative therapies if relevant
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