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This DPP-4 inhibitor is contraindicated in this patient group on the basis of the respective cardiovascular safety study that has shown a significant increase of hospitalization for heart failure as secondary endpoint in the saxagliptin arm (63, 66)

279,280 PU-H71 suppresses cell survival and promotes DNA damage accumulation by inhibiting RAD51 and Ku70 expression and is currently under clinical evaluation, including in combination with carbon-ion radiotherapy

Ames testing showed no mutagenic effects, meaning BPC-157 did not cause DNA mutations in bacterial cells

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