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Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

Maximum voluntary contraction of the knee extensors (a direct strength test): Both absolute and relative muscle strength were preserved

A simple radioisotopic assay of acetylcarnitine and acetyl-CoA at picomolar levels

23 EzakiB.YamamotoY.MatsumotoH

286 Smoking also contributes to increased risks of cardiovascular and metabolic disorders, osteoporosis, and cancer after menopause

, 35 , 971-977, doi: Cao, S