Annu Rev Immunol (2014) 32:659702
Rationale MetS is associated with insulin resistance, abdominal obesity, hyperlipidemia, hypertension, platelet hyperactivity, and other CVD risk factors
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Conversely, forced expression of a constitutively active form of beta-catenin in the epidermis results in ectopic follicle formation: skin that was not programmed to produce follicles begins generating them