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However, the hypoglycemic events (OR value) were significantly higher when the combination therapy included a sulfonylurea than when there was no sulfonylurea, suggesting that sulfonylureas can dramatically increase the incidence of hypoglycemia events

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10.1159/000080345 Cell

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MC5R: While it appears to be expressed across multiple tissues, the precise physiological function of MC5R remains somewhat elusive, though it is speculated to play a role in exocrine processes