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Indeed, selective activation of PGC-1 within the hepatocytes protects the liver from lipids overload and progression to fibrosis, due to its ability to induce mitochondrial oxidative phosphorylation, fatty acids -oxidation and citrate cycle, while decreasing oxidative stress and promoting triglycerides excretion in the bloodstream 15

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These purified HBs demonstrated robust self-renewal capacity, expanding in a small-molecule-defined medium (ACDFSV) for over 20 passages without losing their proliferative capacity or characteristic morphology

this summary covers the well-studied copper tripeptide GHK-Cu (glycyl-L-histidyl-L-lysineCu)

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For example, certain anti-cancer therapies like radiotherapy and some chemotherapy drugs could produce oxidative stress in tumor cells by increasing ROS components and induce tumor cell death