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Some cardiovascular outcome trials, such as the LEADER trial with liraglutide and the SUSTAIN-6 trial with semaglutide, included fracture events as safety endpoints

Clinical evidence suggests these medications may actually improve liver health by reducing hepatic fat content and inflammation markers, though patients with decompensated cirrhosis require individualized specialist assessment

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Many of these relate to tissue remodeling, antioxidant response, and anti-inflammatory pathways

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