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No evidence suggests harm, but definitive evidence of long-term safety does not exist either

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Cattle, Horses, Swine and Sheep - 1 to 2 ml Dogs and Cats - 0.25 to 0.5 ml May be repeated once or twice weekly, as indicated by condition and response

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Unreconstituted lyophilized powder lasts months to years when stored at minus 20 degrees Celsius