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AgRP is classically referred to as a member of the central melanocortin system, which in addition to AgRP comprises -melanocyte stimulating hormone, -MSH (see below for description of -MSH actions) and two melanocortin receptors identified as melanocortin receptor-3 (MC3R) and melanocortin receptor-4 (MC4R)

Obesity is associated with worse RA outcomes, including higher disease activity, reduced treatment response, and increased disability