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TME-mediated cancer resistance and combating strategies The TME in cancer resistance The TME constitutes a critical layer of therapeutic resistance in which immune and stromal cells, extracellular matrix remodeling, and vascularmetabolic constraints jointly restrict drug and immune efficacy (Fig

308,309,310,311,312 This may be explained by the fact that an increased risk of HF may be related to fluid retention, which suggests that this change is reversible

For RAD51 foci, 4 h following irradiation, cells were fixed and immunostained with anti-RAD51 antibody (1:2000

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