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This process is also known as cell turnover and is aided by exfoliation

If the vial had instead been diluted with only 2mL, the concentration doubles to 10,000mcg/mL, and the same dose would require just 0.25mL (25 units)

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Wu, X., Xie, W., Ye, J., Sun, D., Ohnuki, T., Li, M., et al

Injectable troubleshooting Problem: Medication not producing results