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Semaglutide is usually safe for many people
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did not directly point out the treatment potential of GLP-1R agonists for DPN, these results may support the peripheral neuroprotective effect of GLP-1R agonists considering the close association of DPN with adverse limb events (60)
Following GLP-1 RA initiation at the lowest dose with subsequent titration, the basal insulin dose can then be titrated based on clinical response and as informed by blood glucose monitoring (BGM) data
The primary function of the GLP-1R is to bind the GLP-1 protein and its analogs and initiate signaling inside pancreatic -cells to release insulin
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