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It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

McCaig WD, Hodges AL, Deragon MA, Haluska RJ Jr., Bandyopadhyay S, Ratner AJ, et al

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The primary limitation is the gap between preclinical and human data

The effects of interventions with glucosinolates and their metabolites in cruciferous vegetables on inflammatory bowel disease: A review

This expression is inversely correlated with aging (Chen et al