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Lin WH, Huang CJ, Liu MW, Chang HM, Chen YJ, Tai TY, Chuang LM
L., Skuli, N
Examples include: Dilantin (phenytoin) Norvir (ritonavir) and other medicines that contain ritonavir, such as Kaletra Phenobarbital Sustiva (efavirenz) and other medicines that contain efavirenz Tegretol (carbamazepine) Drugs that are metabolized by an enzyme called CYP2D6 Bupropion inhibits an enzyme called CYP2D6, which could lead to increased levels in the body of certain medications (examples are listed below), referred to as CYP2D6 substrates
Further evidence comes from a randomized, double-blind, placebo-controlled Phase Ib clinical trial that also evaluated the efficacy and safety of setmelanotide in obese patients harboring heterozygous LOF variants in MC4R (either complete or partial LOF
Chem Biol Drug Des 99(2):247263
Among the three, compound 1, a unique urethane O-ethyl-4-[L-rhamnosyloxy) benzyl] carbamate, possessed the highest binding energy (-84.99 kcal/mol) (95)
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