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Patients with DPN frequently experience symmetric sensory disturbances, typically presenting as pain, tingling, and prickling sensations and negative symptoms such as numbness [77]
GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRLopesRDet al
These early effects help confirm the compound is active but don't represent full results
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Currently used antidepressant drugs, which mostly target brain monoaminergic neurotransmission, have limited clinical efficacy
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